Character
Reiko Natsume
Reiko Natsume in Natsume's Book of Friends (2008), played by Sanae Kobayashi.
She is/was Takashi Natsume's maternal grandmother and the creator of the Book of Friends. She died mysteriously before the start of the series, so she only appears in flashbacks or dreams. Nothing much is known about her, and the only thing she left behind is the Book of Friends.
Read more about Reiko Natsume on Natsume Yuujinchou Wiki at Fandom