Pharmacist

She rings up the awkward purchases at the local pharmacy, the adult behind the counter when Big Mouth's kids nervously buy condoms, pregnancy tests, or anything else too mortifying to say out loud. Brisk, unbothered, and utterly unfazed by teenage humiliation, she treats every cringe-inducing transaction like just another Tuesday.

Jenny Slate's flat, deadpan delivery turns a background gag into a small comic engine: the show's biggest laughs often come from adults reacting to puberty with total nonchalance, and she nails that contrast between the kids' spiraling shame and her complete indifference, selling the joke without ever overplaying it.