Nurse

The Nurse is a minor fixture of the school's medical office in Big Mouth's hormone-soaked hallways, the kind of adult authority figure the kids run to when puberty turns alarming. She's brisk, unbothered by the chaos of adolescent bodies, and treats every panicked visit as just another Tuesday.

Jenny Slate gives the role a deadpan calm that plays beautifully against the show's constant hysteria — a small, efficient voice of order amid pubescent meltdown. It's the kind of blink-and-you'll-miss-it part that works precisely because it doesn't try too hard, letting the joke land through understatement rather than volume.